Anti protozoal and anti-microbial drug, a derivative of 5-nitroimidazole. The mechanism of action is to restore the biochemical 5-nitro group of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. Restored 5-nitro group of metronidazole interacts with DNA cells of microorganisms, inhibiting the synthesis of nucleic acids, which leads to the death of the bacteria. Active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp., And obligate anaerobes, Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive organisms (Eubacter spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). MIC for these strains is 0.125-6.25 mg / ml. In combination with amoxicillin is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole). Metronidazole-sensitive aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes. Increases the sensitivity of tumors to radiation causes a reaction disulfiramopodobnye stimulates reparative processes. Indications for use: Protozoal infections: extraintestinal amebiasis, including amebic liver abscess, intestinal amebiasis (amebic dysentery), trichomoniasis, giardiazis, balantidiasis, giardiasis, cutaneous leishmaniasis, Trichomonas vaginitis Trichomonas urethritis. Infections caused by Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): bone and joint infections, infections of the CNS, including meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis. Infections caused by species of Clostridium spp., Peptococcus and Peptostreptococcus: abdominal infection (peritonitis, abscess of the liver), pelvic infections (endometritis, an abscess of the fallopian tubes and ovaries, infection, vaginal vault). Pseudomembranous colitis (involving the use of antibiotics). Gastritis or ulcer 12 duodenal ulcer associated with Helicobacter pylori. Prevention of postoperative complications (especially intervention colon, okolorektalnoy area apendektomiya, gynecological surgery). Radiation therapy of patients with tumors - as radiosensitizing drugs in cases where resistance is due to tumor hypoxia in tumor cells.
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